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A 2020 evaluate documented that modafinil contains a modest impact on memory updating, though the effect is small and may not accurately replicate the perception that it is helpful as being a cognitive enhancer, as There exists inadequate evidence to help this type of claim.[249] Article-anesthesia sedation[edit]
The encouraged dosage of PROVIGIL for individuals with narcolepsy or OSA is two hundred mg taken orally once a day as one dose in the morning.
indinavir will improve the level or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
400mg Modafinil: For those needing for getting sh*t completed 24 hrs in a row, 400mg Modafinil can make that transpire. You'll be “cracked” out in a way, but productivity might be through the roof.
Drugs which have constraints besides prior authorization, amount boundaries, and action therapy connected with Each and every prescription.
[eighteen] Serious renal and/or hepatic impairment is understood to cause significantly enhanced continuous-state drug concentrations. Dose reduction is suggested in clients with severe hepatic impairment.
Reassess diploma of sleepiness commonly; if made use of adjunctively with continuous positive airway pressure (CPAP): Periodic evaluation of CPAP compliance is necessary
The performance of steroidal contraceptives may be lowered when applied with PROVIGIL and for a person thirty day period after discontinuation of therapy. Substitute or concomitant ways of contraception are proposed for patients taking steroidal contraceptives (e.
Avoid concomitant utilization of tucatinib with CYP3A substrates, where small concentration adjustments may well bring about serious or lifetime-threatening toxicities. If unavoidable, decrease CYP3A substrate dose In line with product labeling.
elvitegravir/cobicistat/emtricitabine/tenofovir DF improves levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
modafinil will reduce the level or result of copyright topical by impacting hepatic enzyme CYP2B6 metabolism. Minimal/Importance Unfamiliar.
What's more, it has many off-label indications. This action will highlight the system click here of motion, adverse occasion profile, pharmacology, monitoring, and applicable interactions of modafinil, pertinent for customers on the interprofessional group in the treatment method of individuals with circumstances where modafinil contains a therapeutic intent.
cenobamate will boost the level or effect of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Observe Intently. Think about a dose reduction of CYP2C19 substrates, as clinically appropriate, when made use of concomitantly with cenobamate.